Epidermal Biosensor Platform with Variable Recognition Elements

Michael Daniele

Project runs from 09/01/2015 to 08/31/2019
$422,001

This project encompasses the plan to develop a variable node for epidermal biosensors, in which the node has an interchangeable recognition/transduction element that can be modified to act as a biological, chemical, or electrophysiological sensor. The objective in Year 6 is to continue the development of the patch for multiplexed, epidermal biochemical sensing. The patch, as currently designed, incorporates two bio-recognition elements, glucose oxidase for glucose sensing and lactate oxidase for lactate detection. A temperature sensor, a pH sensor and an optical sensor will be included for calibration of enzymatic activity and measurement of relative deoxygenated hemoglobin amount in blood, respectively. The project aims to further validate the operation of the patch in vitro with the intended goal to be approaching the integration with the HET testbed and the design of pre-clinical human subject trials (≈10 individuals) towards the close of Year 6.