Bio-MAPS: BioMolecular-Array Patterns for Precision Differentiation of Intestinal Stem Cells
Using Bio-MAPs technology, NC State researchers are studying the relationship between complex biomolecular topology and cell proliferation, differentiation, adhesion and migration. With the precision of this technology, researchers are creating and testing new biomaterial recipes for ECM-inspired cell conditioning substrates. The goal is to create phenotypically defined cells for regenerative medicine applications.
Sponsor
National Science Foundation (NSF)
The grant—running from July 15, 2021 to June 30, 2024—is for a total of $510,838.
Principle Investigators
Michael Daniele
Stefano Menegatti
Jan Genzer
Scott Magness
More Details
We will harness the precision in controlling the combination, concentration, and presentation of adhesion/growth factors of Bio-MAPs to (1) transform - from qualitative to quantitative - our understanding of the correlations between complex biomolecular topology and the mechanisms of cell proliferation, differentiation, adhesion, and migration. This will provide us with a unique tool to (2) create and test new “biomaterial recipes†for ECM-inspired cell conditioning substrates to be utilized in manufacturing phenotypically defined cells that are “tissue engineering-ready†for direct application in regenerative medicine.