Modulation of Cerebellar Activity by Electrical and Focused Ultrasound Stimulation
This proposal seeks to develop effective modulation paradigms for the lateral cerebellar nucleus (LCN) using electrical and ultrasonic stimulation methods. Aim 1 and 2 will investigate indirect modulation of the LCN through electrical and ultrasonic stimulation of the cerebellar cortex. Aim 3 will merge the two different stimulation paradigms to investigate novel mechanisms at the cellular level. Finally, a computational model will be developed in Aim 4 to simulate the modulatory effects of Purkinje cell (PC) firing patterns on LCN activity, which will be verified by experiments. NC State will develop the ultrasonic arrays to be used in chronic experiments.
Sponsor
New Jersey Institute of Technology
The grant—running from May 1, 2022 to April 30, 2025—is for a total of $447,540.
Principle Investigators
Omer Oralkan
Feysel Yalcin Yamaner
More Details
The overarching goal of this proposal is to develop effective modulation paradigms for one of the cerebellar outputs, the lateral cerebellar nucleus (LCN), using electrical and ultrasonic stimulation methods. The search for optimum modulation paradigms will also lead to an improved understanding of how the cerebellar cortical networks naturally control the LCN neurons. Indirect modulation of the LCN through electrical and ultrasonic stimulation of the cerebellar cortex using novel waveforms will be investigated in the first two aims. The third aims will merge the two different stimulation paradigms to investigate novel mechanisms that can emerge from interaction of the two at the cellular level. The last aim will develop a computational model to simulate the modulatory effects of Purkinje cell (PC) firing patterns on the LCN activity and verified with experimental data. NC State team will develop the ultrasonic arrays to be used in chronic experiments.