Real-Time Continuous Monitoring of Metabolites: Addressing Artifacts, the Elephant in the Room
The integration of wearable devices into healthcare has become increasingly pivotal, offering real-time insights into physiological parameters for proactive health management. One emerging trend is the use of skin as a sample matrix for monitoring metabolites like glucose, lactate, and ketones. While substantial progress has been made in subdermal metabolite monitoring, translating these paradigms into ambulatory settings presents challenges. Our research extends monitoring durations in ambulatory settings, leveraging enzyme-based biosensors and alternative materials like PEGDGE hydrogels for improved performance. However, challenges persist, including noise artifacts and motion-induced disturbances, necessitating novel artifact mitigation strategies like “compensation electrodes” to enhance reliability and accuracy in metabolite monitoring. This study aims to overcome challenges associated with artifact reduction in ambulatory metabolite monitoring using subdermal wearable biosensors, advancing towards more robust monitoring solutions for improved health outcomes.
Furthermore, we highlight the significance of effective metabolite monitoring in ambulatory conditions to provide continuous, real-time insights into individual health status. By optimizing sensor design and data processing techniques, we strive to enhance the clinical utility of wearable biosensors in personalized healthcare settings. This research not only addresses specific challenges in ambulatory metabolite monitoring but also contributes to the broader discourse on wearable biosensor technology and its transformative potential in advancing personalized healthcare.
Sanjiv Sharma
Swansea University on April 12, 2024 at 10:15 AM in EB2 1231
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Dr. Sanjiv Sharma received his PhD on the development of analytical methods for determination of certain pharmaceuticals and their metabolites using miniaturised separation system in 2001. His PhD supervised by Dr Sunil Kumar Sanghi. He then performed postdoctoral research in the areas of high throughput sequencing, clinical proteomics and miniaturised analytical systems in France and Germany from 2001-2004. In 2004, he was awarded a Chevening Technology Fellowship to work with Professor Andrew deMello on microfluidic systems in the Department of Chemistry at Imperial College London. On completion of his fellowship he joined the Institute of Biomedical Engineering, to work with Professor Tony Cass in the area of Bionanotechnology and Biosensors. Here he developed minimally invasive microneedles, from photolithographic fabrication to high throughput fabrication, taking these microneedles from the lab to the clinic. Sanjiv is a Fellow of the Royal Society of Chemistry (FRSC) and the Higher Education Academy (FHEA) He has published over 75 research articles and has patents filed in Germany, UK and the United States. Sanjiv is currently a Senior Lecturer in Medical Engineering in the Department of Engineering at Swansea University. At Swansea, he is working on therapeutic drug delivery and diagnostic (theranostic) applications of polymeric microneedles. He is taking up an academic position in the Faculty of Medicine at the University of Liverpool from August 2024.
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